Irina Calin-Jageman

Biological Sciences
Office & Location:
Parmer 242
Office Phone:
(708) 524-6596

Job Title

Associate Professor - Biology/Neuroscience


My research interests focus on the regulation of gene expression in the central nervous system. Understanding the biological mechanisms of memory is an important goal in neuroscience and fundamental to understanding how nervous systems adapt behavior to novel conditions. Specifically, I study the transcriptional changes that accompany the maintenance and decay of long-term memory in the simple marine mollusk, Aplysia californica. My research program integrates multiple methodologies, including bioinformatics, cell culture, molecular biology, and biochemistry.


Doctorate in Biological Sciences, 1996‐2002 Department of Biology Wayne State University, Detroit, MI


(**With students from Dominican University)

  1. Holmes G., Herdegen, S., Schuon, J., Cyriac, A., Lass, J., Conte, C., Calin‐Jageman, I.E. and Calin‐Jageman, R.J. "Transcriptional analysis of a whole‐body form of long‐term habituation in Aplysia californica." (2015). Learning and Memory, January 22: 11‐23. **
  2. Herdegen S., Conte C., Kamal S., Calin‐Jageman R.J., Calin‐Jageman I.E. "Immediate and Persistent Transcriptional Correlates of Long‐Term Sensitization Training at Different CNS Loci in Aplysia californica." (2014). PLoS One. Dec 8;9(12). **
  3. Herdegen S., Holmes G., Cyriac A., Calin‐Jageman I.E. and Calin‐Jageman R.J. "Characterization of the rapid transcriptional response to long‐term sensitization training in Aplysia californica." (2014). Neurobiol Learn Mem. Aug 10; 116C:27‐35. **
  4. Gregory F.D., Pangrsic T., Calin‐Jageman I.E., Moser T., Lee A. "Harmonin enhances voltage‐dependent facilitation of Cav1.3 channels and synchronous exocytosis in mouse inner hair cells."(2013). J Physiol. Jul 1;591(Pt 13):3253‐ 69. **
  5. Cyriac A., Holmes G., Lass J., Belchenko D., Calin‐Jageman R.J., Calin‐Jageman I.E. "An Aplysia Egr homolog is rapidly and persistently regulated by long‐term sensitization training." (2013) Neurobiol Learn Mem. May;102:43‐ 51.**
  6. Bonnick K., Bayas K., Belchenko D., Cyriac A., Dove M., Lass J., McBride B., Calin‐Jageman I.E., Calin‐Jageman R.J. "Transcriptional changes following long‐term sensitization training and in vivo serotonin exposure in Aplysia californica." (2012) PLoS One. 7(10) **
  7. Dalet A., Bonsacquet J., Gaboyard‐Niay S., Calin‐Jageman I.E., Chidavaenzi R.L., Venteo S., Desmadryl G., Goldberg J.M., Lysakowski A., Chabbert C. "Glutamate transporters EAAT4 and EAAT5 are expressed in vestibular hair cells and calyx endings." (2012) PLoS One. 7(9).
  8. Gregory, F.D., Bryan, K.E., Pangrsic, T., Calin‐Jageman, I.E., Moser, T. and Lee, A. "Harmonin inhibits presynaptic Cav1.3 Ca²⁺ channels in mouse inner hair cells." (2011) Nature Neuroscience. 14(9): 1109‐11. **co‐ first author. **
  9. Lysakowski, A., Gaboyard‐Niay, S., Calin‐Jageman, I.E., Chatlani, S., Price, S.D., Eatock, R.A. "Molecular microdomains in a sensory terminal, the vestibular calyx ending." (2011) J. Neurosci. 31(27): 10101‐14.
  10. Calin‐Jageman, I.E. and Lee, A. "Cav1 L‐type Ca2+ channel signaling complexes in neurons" (2008) J. Neurochem. 105(3): 573‐83.
  11. Cui, G., Meyer, A., Calin‐Jageman, I.E., Neef, J., Haeseleer, F., Moser, T., Lee, A. (2007) "Ca2+‐binding proteins tune Ca2+ ‐feedback to Cav1.3 channels in auditory hair cells." J. Physiology. 15 (585):791‐803.
  12. Calin‐Jageman, I.E., Yu, K., Hall, R.A., Mei, L. and Lee, A. (2007) "Erbin enhances voltage‐dependent facilitation of Cav1.3 Ca2+ channels through relief of an autoinhibitory domain in the Cav1.3 a1 subunit." J. Neuroscience, 27(6): 1374‐85.
  13. Calin‐Jageman, I.E., Wang, J. and Bannon, M.J. (2006) "Forskolin regulates the preprotachykinin‐I gene promoter through a PKA‐dependent, CREB‐independent mechanism." J. Neurochem; 97(1): 255‐264.
  14. Bouhamdan, M., Michelhaugh, S.K., Calin‐Jageman, I.E., Ahern‐Djamali, S. and Bannon, M.J. (2004) "Brain‐specific RGS9‐2 is localized to the nucleus via its unique proline‐rich domain." Biochimica et Biophysica Acta; 1691: 141‐ 150.
  15. Zhang, Y., Calin‐Jageman, I.E., Gurnon, J.R., Choi, T.J., Adams, B., Nicholson, A.W. and Van Etten, J.L. (2003) "Characterization of a Chlorella virus PBCV‐1 encoded ribonuclease III." Virology, 317(1): 73‐83.
  16. Calin‐Jageman, I.E. and Nicholson, A.W. (2003) "Mutational analysis of an RNA internal loop as a reactivity epitope for Escherichia coli ribonuclease III substrates." Biochemistry, 42: 5025‐34.
  17. Calin‐Jageman, I.E. and Nicholson, A.W. (2003) "RNA structure‐dependent uncoupling of substrate recognition and cleavage by Escherichia coli ribonuclease III." Nucleic Acids Research, 31: 2381‐92.
  18. Calin‐Jageman I.E., Amarasinghe, A.K. and Nicholson, A.W. (2001) "Ethidium‐dependent uncoupling of substrate binding and cleavage by Escherichia coli ribonuclease III." Nucleic Acids Research, 29: 1915‐1925.
  19. Amarasinghe A.K., Calin‐Jageman I.E., Harmouch A., Sun.W. and Nicholson, A.W. (2001) "Escherichia coli ribonuclease III: Affinity purification of hexahistidine‐tagged enzyme and assays for substrate binding and cleavage." Methods in Enzmology, 342: 143‐158.


  • Biology 111 - General Biology
  • Bio/Neuro 273 - Neurobiology
  • Bio/Neuro 352 - Cellular and Molecular Approaches to Neuroscience
  • Bio/Neuro 352 - Molecular and Cellular Biology
  • Neuroscience 395 - Research and Creative Investigations
  • Biology 495 - Research and Creative Investigations
  • LAS 445 Good Life: Fate and Responsibility